One thing to remember about shooting game in the 100 to 200 pound range is retained energy. You may be able to hit a deer at 300 yards with a 30-30 or 7-30 Waters from a pistol barrel but you will not have a lot of energy left for expansion of the bullet and a quick kill if you are using rifle bullets. You will need to use one of the special bullets made for Single Shot Pistols like the 130 gr. SSP 7mm and the 135 gr. SSP 30 Cal. that Sierra makes. That means that you must handload. With factory ammo I would limit my deer shooting to inside 150 yards.