1 it takes a minimum of 10 shots to get meaningful results (the more, the better data)
Getting low SD/ES has become fairly simple. If I have low numbers but poor groups/fliers it generally because the load is too hot.
I keep backing down til I get consistent.2 to .4 groups.
For me consistency is the key to low SD/ES.
Most important- good brass and bullets (consistent bullet weight and bearing surface)
Consistent headspace is often overlooked and has a big impact as well as the right primer.
Generally not loading hot helps.
Amp Anneal every time, Henderson trim,
I full body neck size & mandrel (however know others that don't mandrel and they get low es/Sd)
SuperTrickler powder dispense +/- .02.
Good temp stable powder helps to keep things in tune.
Shoot ladder in 3-shot groups to find my powder node.
Usually if I follow these steps, within 21-30 rounds I find my load. Then fine tune.