Jon, As already stated, you case neck/shoulder was not supported properly when you originally fire formed the cases. I load for 250ai, 257ai, 7x57ai, 280ai, and 243ai. Only saw this once while forming 257ai and was the result of lack of support at the neck/shoulder. The damage was done on first firing and created a weak point in the case which stretched at that point on subsequent firings. You would need to check for pressure signs at the case head to see if they are over pressure. Ackley chambers today arent as tight as the ackley's of old. Ackley set his chambers back .004' to prevent this. The best way to prevent this is to form a false shoulder in the neck by running your virgin 22-250 brass over a 6mm mandrel and then back your ai size die out a half turn and size the neck back down. Try it in your chamber, if bolt wont close, turn the die down 1/8 turn, size, and try in chamber again. Continue this until the bolt closes snuggly on the round. Size the rest of the brass, load and shoot. The false shoulder will hold the case head against the bolt face and prevent this excessive case stretch. One way to check you chamber is to try to close the bolt on a standard 22-250 go gauge. It should NOT close on it. In ackley chambers properly done, the parent cartridge (in your case, 22-250) go gauge becomes the no go gauge.
Fortunately, it appears the leaked gases went forward as indicated by the soot on the shoulder and neck