IMHO, yes. With the right bullet choice(s). I have taken many animals in Alaska with my 308s. I've taken mature arctic bull moose which are much larger on average than moose further south. I dropped another mature bull at 440 in the Mat-Su valley. Taken black bear, caribou, a pile of dall sheep and black tails. Longest shot was 763 on a dall. One shot. Wolves too. I've taken coues white tails and mule deer with the 308 as well. For me, I can shoot a lot more with the 308 due to long barrel life. You can really get proficient with it without the barrel changing every 50 rounds like some other barrel burner magnums. I have loads that match the energy of my 6.5PRC at the muzzle out to 300 yards. Of course, my PRC blows it away as the distance increases but out to 300, I prefer my 308. At 600 yards, I'm only giving up 120 pounds of energy to my 6.5PRC. Windage is different but from a terminal ballistics standpoint, it holds it's own. Look to 190-210 grain pills for the best 600 yard values in energy and windage. Also, with the heavier bullets, slower powders are best. H4350, RL17, VV-N540-550 all work well. I get 2650+ with 200 grain pills under H4350 in 26" barrels. 550 is another great choice for 200+