My experience has been that seating depth effects group size. Different rifles, bullets, loads etc all react differently to seating depth changes. All of my rifles, except my lever actions like .018-.021 off the rifling. I find my best node with combinations of brass, primers and charge weight. then I muck with seating depth. Its amazing how I've found something that I thought was a node that didn't become a node until I tweaked the seating depth. My .270win likes .020 off the rifling, that was with a 150gr NP. Out of necessity I had to move to a 150gr ABLR and had to go to .017 to get an exceptional group out of it. Other things, like neck tension, neck thickness add to the equation also, once I had a concentricity issue throw me a curve too.