I made my longest shot ever this year; 429 yards, 6mm Rem, muley doe. I missed the first shot, under her, and she didn't even wiggle. I quickly reloaded and adjusted appropriatly. At the shot she looked drunk, one step to the left, three to the right and then fell on her beak.
What fiftydriver and others have said before I have found true; when shooting animals from longer ranges they are less stressed and un-scared. Also any animals with them dont get scared and run off stressed. What I have seen is they just get a little nervous and move off.