Nosler Reloading Guide number 4 lists IMR4895 as the most accurate powder tested. That's were I started with 50 Gr V-Max. Shot better than any other load I've used in my 22-250 thats the load I've been using now for three years. 3800 fps +. One exception I stumbled across Benchmark which is also an awesome 22-250 powder more velocity than the 4895.