I've shot a couple cows dead on the heaviest shoulder bone possible with a 140 VLD starting at 3234 fps, both within 300 yards and it blew the leg bone to splinters, entere the chest and destroyed the lungs and major vessels and either ended up on the of side hide or on heavy quartering up in the of side of the neck.
I've dispatched quite a number of bulls and cows with a shot to the base of the neck and I've never had one not break the neck and most exit. My buddy broke the neck on an Alaskan bull moose with them as well, his first shot took him frontal and exited the flank after messing up his lungs pretty good then the second was a neck shot from a 6.5x284.
Never caught one in a deer even mule deer through both shoulders exit, one of my favorite bullets for elk but I normally keep everything in the slats cause I want more meat!