I don't like that combination. Terrible balance for a carry rifle.
Only way you'll know is to try it. The rifle will want to be carried upside down.
I mounted a 30oz scope on an 8lb 300 Win Mag and carried it for 2-3 hunting seasons before I couldn't stand it any longer. But I backpack hunt. My rifles are carried a lot. For me, the decision was based on how much I pack the rifle around. By backpack hunting, I mean I'm carrying a 45lb backpack on the way into mountains in search of sheep, caribou, black bear, Mt. goat, etc., plus the weight of the scoped rifle. The rifle gets carried a lot more than it gets shot. I put up with the anchor mounted over the receiver until I decided it just wasn't any fun carrying the rifle with that heavy scope any longer. The extra weight was notable and a nagging source of disgust. In addition to the additional weight, on a relatively light rifle, the unbalanced rifle wanted to roll over while carrying it in the elbow joint - shotgun style. It got to be something I resented having to carry around.
If you don't carry the rifle extensively, then the only other primary point of irritation I experienced would be when setting the rifle up in two sandbags at the range or next to camp, or resting it atop a field-fashioned rest preparing to take a prone shot. The top heavy scope would tend to roll the rifle to the side whenever I'd leave it to tend to other matters, or even upside down when in the sand bags. I don't use a tripod, and never have. If you mount a tripod on your carry rifle, that would minimize the second issue I had with my top-heavy rifle. I don't use a tripod because I won't carry that extra weight.
If my rifles weren't packed extensively, I could have lived with the extra weight and top-heavy, unbalanced rifle. So again, for me, it would come down to how much you'll be packing the rifle around, and in what type of terrain. Rifle carry on flat ground is less fatiguing than up and down sloping terrain, while fighting brush, alders, and willows. For what it's worth...