deathwobble,
From what you're describing here, you're looking at a worst case scenario, regardless of which one you go with. Large capacity cases are harder on barrels than smaller ones (pressures being equal), higher pressure cartridges are harder on barrels than lower, and heavy bullet loads are harder on barrels than lighter bullets. Throw varying flame temps between various (double or single base) powders, and you begin to see how many variables are at work here. On top of this, you need to consider "how" barrels go bad. I've never seen one just suddenly stop shooting. A good quality barrel will continue to shoot outstanding groups, but you see in increase in flyers, first very slightly out of the group. As the round count climbs, those flyers become both more frequent, and will tend to move further away from the centroid of the group. At some point, you just have to admit that it's time to pull the plug, because that barrel is dead. In my work, I simply didn't have the time to waste it messing with a questionable barrel. I also kept logs on each barrel, and when they approached the point where similarly chambered barrels had died, I began looking for signs that the bore was gone. With a standard 308 Win, that was usually around 3,500 rounds, give or take a few hundred. With the 300 WM, 1,200 was usually about as far as they went.
Barrels are expendable, and if you're going to play certain games, you need to wrap your mind around that fact. They're "perishable tooling," and nothing more. From what you're saying you want to do here, I'd say somewhere around 1,000 rounds is a pretty safe bet, and wouldn't count on a barrel going much beyond that, if that far. Cost of doing business.