That pretty much depends on what you want to hunt.
Elk hunters have a pretty big kill zone to hit while those who hunt Prairie Dogs have a fairly narrow one.
I hunt coyotes, but I don't leave them lay or let them run off wounded. I lose a couple each year, but not for lack of effort on my part.
Coyotes give me a 4" kill zone. My range is limited to the distance I can shoot groups 4" or under.
A 1/2 MOA rifle will give me only 800 possible yards of range.