There really is only one cause for hangfires, too little of a slow burning powder. When there's too much air space in the case, the primer ignition doesn't compress the powder enough and the granules fly around the primer flash and do not ignite properly, maybe 1-2% of the charge ignites, delaying the proper powder compression, then when the correct compression is reached the powder ignites the way it should. This phenomenon is what is believed to be the cause of S.E.E (Secondary Explosion Effect).
Never reduce loads below the start loads in large cases with powders from H4350 through to the slowest, especially double base stick or ball powders. The bigger the overbore ratio, the worse this gets. I built a 25WSM with a 26" barrel, it would hangfire at 5% below max and dent the case bodies the full length of the case, it would also soot the cases when ignition was poor with slow powders, max loads were the only way to keep it burning correctly.
Hope this helps.
Cheers.
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