The best method I have found is the OCW (optimal charge weight) method for my 7mm Rem Mag, and all other calibers. It was started by Dan Newberry years ago. What you are doing is similar, except I shoot round robin like Dan does, and 100 yards is just fine. Two minutes between shots, and take a few fouling shots before you begin. I usually use 5 to 6 different charges, hence 5 - 6 targets. I also use QuickLOAD and a LabRadar. This way I can document everything I need accurately, especially the true burn rate of my H1000 at a given temperature while at the range. I don't get hung up on extreme spread and standard deviation anymore, and just go with what I see on target. You will find your optimal charge weight, it just takes time.