Your ability to place the shot precisely is the only real consideration as long as you are using a quality bullet.
We occasionally need to remind ourselves that the 6.5's have been used for a century or longer now to take all European big game and even most of the big game in Africa less Hippos, buffalo, Rhino, and Elephant and is probably the most popular bullet size for the plains game there.
None of the Euro 6.5's though have even quite the punch of the 6.5x284 or .260 Rem.
You Must put it in the bread basket hower unless you are shooting shooting at relatively close range with Solids or solid nosed bullets because our LR bullets are not likely to beak bones and punch shoulders consistently in the 6.5 class.