I have a 6.5-06AI semi custom built on a Howa 1500. I use 30-06 Lapua brass and run it fairly hard and get right close to 3200 with Berger 140's out of a 27.5in Lilja 1-8 and it shoots great, zero complaints with how it shoots. I also have a semi custom 6.5-284 built on a Rem LA 700 with a 26in. 1-8tw Shilen. It has more of a standard length throat so it, maybe, is giving up a little velocity but I doubt it's much. My 6.5-06ai definitely shoots faster but it's not some huge amount faster and IMO is NOT worth the extra work or expense. Both feed perfectly fine.
Just last week I was talking to Shawn Carlock w/Defensive Edge about doing his +P throat on my 6.5-284 because he gained a pretty decent amount in his 260 Terminator with the +P throat so if I gain the same 120fps in my 6.5-284 that he did in his 260 Terminator, I could very possibly have a 6.5-284 that'll shoot the 140's 3200 or slightly more, out of a 26in barrel.
If I were looking to build a new hot rod 6.5 and wanted to stay with a standard bolt face, it would be an easy decision, 6.5-284 is what it'd be and if I thought I wanted a little more performance than what the 6.5-284 could deliver, I'd talk to Shawn about doing his +P throat to it.
For me, it's a no brainer, the 6.5-284 is just so darn easy. You can use Lapua brass, there are very good dies readily available and they just always seem to shoot very well. The 6.5-06 is pretty much identical in case capacity to the 6.5-284 but the 6.5-284 is basically a load and go cartridge and, if need be, has factory ammo available. The 06 case gains very little when improved and having had both, I don't think it's worth the extra time or cost.