I have work on one ( 338/50 short 35 deg
shoulder ) making case need a full tooling shop equipement , barrel in 338 cal with 2 inch diameter are very very costly ( 40 inch lenght ) but that fun if you are mecanical skill and fully equiped .
If you go in 338/50 carefully check carbon fouling, too much powder capacity of canon powder in a small bore is a nightmare .
on 50 BMG I think that 0.375 cal on short case ( 2.5 inch ) with long neck can be the right solution to balance water capacity case and bore ratio .
now with 408 case that possible to make more simple if you have a good action , main problem with big case is to find a good big action and reasonable price and AVOID any small action modification .
I have now a 338/378 Wea tight chamber 34 inch closely finish that will work fine under 2000 yards without too much additional cost
good shooting
DAN TEC