RE 22 is to slow for the 338 win mag. H-414 to RE 19 is the range for this cartridge. With the 225 grain bullet 4350 and RE19 are very good. You should be able to work up to near 2950 fps with the 225 CE in your 26" barrel. I love the 338 winchester because it will kill anything inside 1000 yards in a light rifle with no muzzle brake. The cartridge is extremely accurate in a good rifle. My longest kill with the 338 winchester and a 225 grain bullet was a huge Alaskan moose at 1104 yards. Have made many shots with the cartridge in the 600-800 yard range. It hits animals hard with authority unlike the smaller caliber cartridges off this case. The 7mm remington, 264 winchester, 308 Norma, and a few others are all off this case just necked down. Not that the others will not do the job, just the 338 hits noticeably harder on game.