I have just never used any 225 in anything! ha I have always had a "heavy thumper" for woods/medium range and a lightweight Mono/NAB for a flat shooter ( 375/400 my limit) My furthest kills with Medium calibers are just a few; cow elk at 250yds/185xlc 338; Aoudad at 250yds/180NAB 338 RUM;Black Wildebeast at 347yds/200x 35 WAI; zebra at 250/200x 35 WAI; all the rest of my 350-375yd shots were with either a 257W or 300WM. Shot a wad of them 200 and closer with 33-375s. They get that "Oh MY God, I've been shot!" look on their face! ha