The real problem with the 375's is bullet selection. Most 375 bullets are close-up smasher types, made for heavy game/safari. The high bc bullets are heavy enough to require Cheytac sized cases to make them worthwhile.
I have a 375 H&H, which I have tinkered with to get an idea of its long range potential. While I came up with some interesting results, I think the .30's and .338's are a better, more practical choice. If the right bullets were available, the 375's have a lot of potential. I pretty much shelved my 375 load work unless/until better long range hunting bullets become available.