I'm on my 2nd barrel and will continue chambering 300 PRC's. With both barrels right off the bat I've had great success at getting tight groups and decent MV spreads. The SAAMI chamber is a functional match chamber. No belt, no rebated rim-- not that those are always, or even often deal breakers, but it's two potential issues that don't exist.
I disagree with JM about bullet weights. I'm shooting 230 and 250gr A-tips out to a mile with very good results. Inside of 1000 is boring, 1000-1700 is pretty solid, and after that gets dicey, but IME it gets dicey with pretty much any cartridge at those ranges. Out to 1200 or so, the factory 225gr ELD's are very effective and consistent.