Didnt know the weatherby vanguard came threaded only caliber I would want with threaded barrel would probably be 300 win mag maybe 7mm mag only for muzzle brakes dont have a can yet
A Silencerco (SiCo) Omega works very well for me on a variety of platforms. I can direct thread it for about 14 ounces of weight but, normally just use Quick-Detach mounts. The muzzle brake mount works pretty well at taming things down for harsh cartridges and, the flash hider is great for "Walter Mitty" adventures assuming non-NFA barrel lengths or really cheap high flash powders and loadings (WWB AR-15 blaster ammo for example).
The muzzle brake on my KAC SR-15 Mod 2 LPR is super smooth and has basically non-existent recoil. With the SiCo ASR muzzle brake, I literally have Ruger 10/22's that recoil harder. It also works exceptionally in the field; I shot a ~30# dog coming straight at me at about 80 yards after watching it a bit and put the round on target and watched the rear end come over the top. It was like that dog coming at me hit a wall at full speed. Does that rifle need a muzzle brake, no not really. However, being able to shoot and not having the reticle move certainly helps with assessing whether a follow-up shot is needed with a dog at full run.
The Vanguard series has models come and go so, whether they have threaded factory options at any given time is a bit of good or bad timing at the moment you look. In my case, #3 barrel with light fluting was tailor-made for what I wanted.
Normally, I'm not a good advocate for Weatherby options but, the little 257 Weatherby won me over. When you move up to other options, recoil and muzzle blast increase and power levels are just excessive for a lot of my uses. I thought about a 264WM but, this won me over. Heavy 6.5mm, 7mm, etc. really get into their own IMHO with heavy game animals though, 6.5mm or 7mm 'magnum' will certainly nail a small deer very hard.
Being able to zero coyote loads for no hold over/under out to ~400 yards and feral hog loads to ~300 yards is hard to ignore. Since most of my shots are inside 200 yards, my elevation and windage concerns are negligible. Having a softer kick to the shoulder is helpful considering I have had it rebuilt once already!