I've shot things as close as 25 yards and as far as 350 yards. The bullets perform - animals just pile up dead. I like the TSX bullets, as they're hollow-point, and you can hear the impact immediately so if you come off target during recoil, you have one indication of a hit. And the bullets penetrate incredibly well. Have used TSX in 257 Wby, 300 Win Mag, 300 Wby, 375 H&H. They just work.I just loaded a bunch of those and am waiting to shoot them and evaluate. 3500 fps should work well with the Barnes projectiles. What has been your experience hunting with them and at what distances?