I've used the standard Barnes Vortx .25-06 100 Gr TTSX load for two years now in my Weatherby Vanguard S2 and it has consistently performed for me on Wyoming Antelope, Texas whitetails, hogs, and coyotes from 75 to 408 yards. Most were bang/flops with one high lung hit pronghorn being the exception, but she expired very rapidly. Violent expansion, awesome wound channel. Just pay attention to your velocities and charts, they do not perform well under 2000 FPS which in my .25-06 is just at 550 yards, about as long as I would attempt a shot anyhow. Accuracy is just under .75 MOA in my rifle.