I have over the years fiddled with the 22LR/22Mag in various rifles. In most cases they were specific to economy of scale target practice, shooting squirrels, raccoons, skunks, fox, prairie dogs and bobcat.
The primary problem was none of them worked or functioned in the same manner as my 243, 7-08, 308, 30-06 or 300WM. All were on Rem700 actions.
Several years past a friend asked me what I taught of the 22 Hornet. Having owned one 50 years ago I told him to buy one. He did a CZ 527 American.
After a couple of desert coyote hunts. I was so impressed with his rifle that I bought one. True 22 Hornet ammo isn't on your local shelves. BUT, I reload so a set of dies, lots of Hornady brass, bullets, and Lil-Gun have made my life so much better.
I've been using mine all most twice a week to hunt coyotes, bobcats, the stink rats, and prairie dogs. I gave my son all of my 22LR rifles. Only keeping my 9422 22LR lever action Winchester.
My CZ is setup just like all my big game rifles. NightForce 3-15 x 50 NSX, harris bipod, home made cheek rest. I pillar and glass bedded the action.
Results coyotes to 300yds, prairie dogs to 380yds, skunks wherever they show up. One buck deer at 150yds on private property in Texas. Which made my hunting buddies eat crow.
Cost overall is reasonable, brass 400 pcs, 13grs lil-gun, 40gr Sierra Blitzkings, and Sierra 40gr Matchkings. Accuracy is awesome.
Within the 400 mark any small game takes a ride home with me.
Good Luck