I'm personally a fan of the higher velo monos on deer out of the .22 calibers with distance of the shot as the deciding factor of if I'm going to shoot or not.
I had the pleasure of having two doe tags this past fall and I had just finished a 24" .224 Valkyrie... so I had to try it out. I didn't have time to do a hand load work up so I just purchased a box of the 78g TSX load by federal, dialed in the rifle and chronoed it... I was receiving 2873 fps. The girlfriend and I set out and finished the same day.
Her shot 180 yards, Between the ribs behind the front shoulder on entry and dead centered a rib on exit. 20 yards and tipped over.
minimal blood shot on the entry, but the exit was worse, I assume due to the bone impact.
My shot was 200 yards. I was trying to recover a bullet because I wanted to see what it looked like and to test the Valkyries penetration. Quartering away, behind the front shoulder hoping it would lodge in the offside shoulder.
Unfortunately for me, it didn't hit any bones and was still an easy pass through. Stoned her. She didn't take a step.
So tying back to the thread and OP in my experience and personal opinion, the .22 Creed loaded with monos would be a an adequate deer gun in a pinch. The velo difference between it and the Valkyrie would bump it up and make it effective on bigger bodied deer/bucks and extend the effective killing range over the Valkyrie which I learned had no problem out to 200.