Years ago I re-chambered a new 9 twist 223 Rem barrel to 22-250 to shoot the Sierra 65 grain Gameking (#1395). It is about middle of the road for what you want to do. Tough little bullet. Killed quite a few deer and g'hogs with it. I didn't find a need to switch back and forth between bullets. With W760 powder, and a WLR primer it gives good accuracy and velocity. I picked up some Sta-ball powder and am going to test that this weekend. Now that barrel is almost at the end of it's life and when it is time, I think I'm going to switch it over to a 243 Win with an 8 twist to shoot the 55-95 grain bullets. More horsepower and capability of higher B.C.'s and with the 55's........really fast.........of course with the loss of some barrel life. Might be some things for you to check in to and consider.