Either of those will work. I run a heavy 26" 22-250AI in 1/8tw, and since I had a large supply of 4831 on hand, I developed a few loads with it using different bullets. With various 75gr's, I was reaching 3.400+fps with very good accuracy, and 3,300+fps with the 80gr versions. After a little experimentation, I found 7828SSC would easily push the 75's beyond 3,500fps and the 80's beyond the 3,400fps ranges with superb accuracy.
I had that rifle built with 1,000+yd targets/varmints in mind, and I have pushed the 80gr's out to the 1 mile mark.