I believe Sierra's new manual has a 22-250AI listed with 80 grain MK's if I remember correctly.
My 22-250AI was designed with Federal brass in mind so that is what the reamer was made for. My gun liked 75 grain amax at first, but once the barrel got worn, it decided it would only shoot Nosler 80 J4 or Sierra 80 mk's. My load is 42.5 grains of H4831sc and Fed 210gm primer. It shoots at 3350 from my 25.5" barrel with very uniform velocities.
It is a fun gun to shoot and I have killed many chucks past 1000 yards with it but when it finally gives up the ghost, I will never do another one! It gets hotter 2x quicker than my 6br fast twist, burns 12 grains more powder, and really isn't any better ballistically at 1000 yards. It is a tad flatter but no big deal. Just dial in a few more clicks and your good to go.
I will probably redo that barrel to a 6-250 improved when the time comes. Way better barrel life, better knockdown, higher bc bullets, and not really any more difficult to make brass for. Just run a tapered expander ball through 22-250 brass and then fireform. Piece of cake.
Just my 2. /ubbthreads/images/graemlins/wink.gif