I had my 8 twist standard 22-250 27"shilen barrel throated to shoot the 75 grain A-maxes. It shoots very accurately... with H-414, W760 & killer groups with AA 2700 with a Fed 210 primer.
I built it for long range ground hoggin'.... I wanted to buck the wind etc.. blahhh.. I got to where I could hit the hogs a long range with some regularity, but the bullet wouldn't dispatch them... lots of draggers gettin' back in the hole. I've heard everything .. you need a swift you shulda made an 22-250AI or a 22-243 or what ever.. I was bummed. So I found a lot of 68 grain Starkes Red Prairie varmint bullets and it's dispatching the hogs better.
Here is the 22-250 8 twist
To totally remedy the problem I built a 243 Ackley Improved for the long range groundhogs and I don't have many draggers anymore. I have been much happier with it's killing performance.
The 22-250 is so accurate though, I could shoot a varmint for score BR match with it...