Try start at 34.5 gr. with H4350 & 75 ELDM's. My rifles use 35.0 H4350 & AA 4350 with the inexpensive, available, low form factor & pointy 75 HELD bullet.
RL16, a double base powder, might be absolute best for 75 grain .22-250 loads. No RL16 seen lately.
A .22-.250 quick twist with 75's is a much-underrated round & compares favorably (not necessarily better) with many 6mm's & .25's that use more powder & have more blast. Lots of inexpensive zip but not enough momentum to tip over long-range steel or hear nice loud splat sounds. Small rifle primer .22-.250 brass would be much appreciated.