I have customers using rifles I built, chambered in .22-.243, cleanly taking coyotes at 1000yds. If that ain't LRH, what is?! They 'stepped up' from the 22/250 because it couldn't do the job. The .22-.243 has a 'following',,,, a substantial following' & loading data available without looking very hard. The .30/.50BMG would be something to play with,,,,, velocity for the sake of velocity. The .22-243 has a practical use (LR varmints), I see none for the .30/.50BMG. I don't even see where one has any bearing in the discussion of the other.