Me and my hunting buddy both used the 210 TTSX out of our 338's to kill our bulls last year. Mine at 630 yards that traveled diagonally through a very large bodied herd bull. Bullet landed hard on the front shoulder, traveled through both lungs and severed the pulmonary artery just above the heart, and exited diagonally further back out the ribs.
My buddy shot his satellite bull from 430 yards. His first shot was with the bull facing him slightly quartered and the bullet entered the front chest, hit the heart/lungs, and exited out the rear ribcage. the bull turned and was moving away from him and the 2nd shot (although unnecessary in hind-sight) entered the rear back and traveled all the way through the body and stopped under the hide in the low/front chest.
We had several reasons for using the 210's over other bullets, but in the end they simply shot more accurately out of our guns than anything else we tried. In the end we had two elk down and those 210 TTSX's sure did the trick. I would not hesitate to use them again. I think they are fantastic bullets for up close, and their accuracy makes them great out to medium distances. At longer range they leave a few things to be desired that other bullets might do better.