I've used 175gr Mk's in a 1-12 twist before... they seem to shoot just fine from a longer barrel rifle {.308 Win}.. say 26" plus. I shoot a 27.5" inch in 1-11 right now using the 175gr Mk's they work great. For shorter barrel rifles, I like the 1-10 twist in fact I like the 1-10 twist Polygonal'..., from Pac Nor.
The load that works best for me is in .308 Win; 175gr. Mk, Federal 210M primer, Lapua brass, {43.5grs} RL-15'..., vel's 2650 fps with very low SD's.
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