If your asking about the same bullet leaving at the same velocity between two different calibers then no, there will be no different outcomes on the same target.Let's say we are working with a 124gr Hammer Hunter……and just pick 2 calibers that are in the same ballpark. If a load is developed generating 3200fps muzzle velo for both calibers, is there any real difference in the 2, provided the bc is equal ??