At the encouragement of a man who hunts for a living I used A-Tips in my 6.5 SAUM @3000 fps on my last deer hunt. At 300 yards a large doe expended her lungs out her off side ribs - with a significant/stunning thwack factor. That's just me. One guy. One time. But the friend who encouraged me to try that uses the exact same thing, at the same speed, for everything he shoots, and that includes everything from big game to small game and coyotes, too.
Someone from the target shooting world asked him, while I was there, why he used such a large setup when a smaller rifle would do. He said, "Cuz I want them dead. I don't want runners. Once I shoot the first one I want to be able to concentrate on the next one, whatever that is."
As for accuracy, the top shooters in PRS are split between Berger 156s and 153 A-Tips in the 6.5 cartridges.