The 257 wthrby is a great cartrige. The round has been used for the African Cape Buffalo, Roy Weatherby proved that.
If cost is a factor then stay away from any Weatherby. As for burning up the barrel fast, yea. But if you can afford to run enough ammo through it to burn it up, you can afford a new barrel every now and again. Every gun will eventually burn a barrel up, some sooner than others and the 257 is one of those. But, there are those calibers that are harder on a barrel.
The only flatter caliber in it's class is the 257 Hot Tamale.
I love the round for just this reason, it's FLAT! On whitetail it is rather damaging on this game under 200 yards if you use the higher velocity rounds. Stay with the heavier 115 gr if you intend on whitetail under 200. I did a lot of research and about this very issue, it only took one deer before I was a believer. I shot a buck at 130 yrds with the 100gr and I got out with two backstraps and two hind quarters. The gun is very distructive on medium sized game under 200yrds, so pick the heaviest/slowest round you can. I have shot many whitetails with the 257wthrby and have never lost an animal. Some drop in their tracks and the others might run 30-40yrds .
I have also shot large 200+lb hogs with this round and had no problems.
The 257 wthrby has an awesome MPBR.
Keep in mind that the 257 is a very distructive round on small/medium size game. I shot a 140lb doe at 603 yrd and it exploded the internals. It has been said by other members on this post and as much as I love the 257 wthrby, there are better calibers for whitetail/pronghorn under the 200 yrd mark.
The caliber is definitely not ideal if your goal is to punch paper at a grand. I have seen boxes of ammunition go for any where from $65 - $100 per box.