Agree with Hogghead, under conditions he states, e.g., Eastern groundhogs.
Personally, I use a 223 close range, less than 200 yards. At a greater distance, I use a better distance shooter... 22-250, 243 or 25-06, depending on what I have with me. My 223 is good for 300 yards, but not great. I've never even tried it more than about 270... and that one was a hole diver (with blood trail).