If you're loading single stage and weighing charges, Varget cannot be beaten. It's magic dust for 308 and 556. Stable, high velocity, and excellent consistency. It doesn't flow well in powder throwers on progressive presses or bench droppers though.
For high volume progressive reloading, CFE is really hard to beat. It's cost effective, high velocity, and meters extremely consistently. Not very temp stable, and not as consistent as Varget, but as fast or faster velocities.
Both powders are great for 40-77 grain bullets. My favorite loads with either powder run 62 gr HPBT or FMJBT bullets, at about 2825 fps from a 16" barrel, quite happily. Either will run bit hotter, but I don't see the need.