I shot a lot of coyotes with FMJ 22, 243, 264. Freaking tough buggers run off and die, or get back up and run off and die. Lost more than a couple. I use just a standard cup and core bullet. My buddy shoots and buys pelts to sell so he knows what people are using and the damage results. He said the best ever is a 17 cal and loves the 17 Rem just almost no one uses it. For 22 he said the 60 Partition is the best. All the others he likes a bonded core or standard bullet.