I don't know anything about the gun, but cartridges in PD towns yes.
For shots out to 300 yds (let's assume there's going to be some wind, usually alot of wind) the 204 and 223 are good. 204 beats the 223 with normal weight bullets IMO.
For shots out to and beyond 300, maybe even out to 600 and 700 (depending on the wind) most prefer the 22BR, 22-250, 220 Swift, 22-250AI, 22-243 varieties.
For shots beyond 400-500 yds and when it's windy; 243's 6mm's, 6 BR's, 6 Dashers, 243 AI's and 6mm AI's, 6-06 and 6-06 AI, 6-284, 25-06 and the 257 Ackley. Some are also going to the 260, 6.5-06 and 6.5-284.
Opinions are like Azzholeos, but my opinion is that the 22 BR, 22-250, 22-250AI, 220 Swift, and 22-243's are extremely good for the majority of dog shooting. They are easy to shoot all day long, not much recoil. They buck the wind better than the 204 and 223 (again, normal bullet weights) and don't cost as much to shoot as the big 6mm's, 6.5's and 06 based cases. They are also about the biggest "bang" I can shoot on 16X to 20X without a spotter to call my shots (unless the gun weighs 15+ lbs and has a good brake on it).
It's not very easy to get ranges on prarie dogs, even with the newest and best rangefinders; so flat shooting is also important. It's not just about high BC bullets and low wind drift when PD's are on the menu. We've gotta have flat shooting and extreme precision too. The status quo "1/2 minute" rifle really struggles on PD's once the distance gets beyond about 400 yds. What we are really striving for is one hole at 200 yds and 1" or less at 300 yds.