I do a ladder at 300, get my data and choices from there, then test loads at 300. Everything through a chronograph and EVERYTHING documented and recorded.
I find it far more accurate and easier in the long run to do it at 300. The only difference in 300 and 100 is the additional 200 yard walk but if the targets and testing is set up right, it's not that big a deal.
Just my $.02
POI's are expanded 3x on Target your exactly right that's why instead of wasting powder/primers/bullets exc. I shoot 100 then 200 then inter it into exbal and bust targets with less wasted ammoAgreed. The only reason I might start at 100 or 200 yds is if your shooting location is windy the day you have to shoot. I would then wait for a low to no wind day and shoot at 300. I find it easier to detemine if the load is going to be a winner at 300 yds. POIs are expanded 3X on target.