I've tested a few versions of the Game Changers in ballistic gel and I'd say they're a pretty soft bullet. I bet they'd be pretty good at low to moderate velocities, but they could get messy with a high velocity impact from a 28 Nosler.
I was using the 140gr .270 Game Changer in a 270/338 Rum Improved wildcat about 2 years ago and it cost me a very nice black bear. That particular gun was incredibly picky about bullets and the Game Changer shot groups half the size of anything else I'd tried. I was in a rush to get this particular gun ready to roll for bear season so I thought I'd give it a go. Most bear here in WA are under 200# and no tougher than an average deer, so I wasn't really worried about using a relatively soft bullet.
I had an easy 250 yard shot on a very nice bear that was likely 250-275# or more on the first weekend of bear season. It couldn't get any easier, a very slight quartering towards me target, feeding without a care in the world, I was sitting with a stump as a solid rest, and the rifle was zeroed at 250 yards. I shot, heard the impact, saw the bear roll, then get up and briskly WALK away. I didn't get a follow up shot before he was into the berries and over the ridge. I found hair at the site of the impact and could see where the bear was walking away dragging one foot slightly. There was very little blood, but that's not unusual for a good sized bear. I tracked that bear for 2 miles hoping to find him and finish him. After about one mile he stopped dragging the one paw and was walking relatively normal. After trailing him for about 2 miles total over one ridge and down into the next valley, I called it off. I saw a large bear later in the season (out of range) with a superficial wound on his shoulder that I believe was the same bear.
My guess is that I was a little too far forward with my shot and hit the bear's shoulder blade, and the bullet blew up. My muzzle velocity was 3560 fps with that bullet, so the impact velocity would have been over 3000 fps at 250 yards. I quit using that bullet and just settled on larger groups with a 156gr Hammer Hunter as a hunting bullet.
I'm sure you could effectively kill elk with the combo you're thinking about, but I personally wouldn't make it my first choice.