Yes, there are a number of rifle and pistol shooters that shoot with an offset scope but they are usually punching paper or steel at known distances and have the opportunity to sight in at that distance. The reason I am concerned about correct tracking is the first shot from your weapon, and that may be anywhere from 100 yds out to 1000yds on the living. If you set your scope up to hit dead on at say 100yds and it is canted, then you range and click up to take a shot at say 800yds on a deer, your bullet will not impact where you were aiming. Try it. Set your rifle on the bench in the position you normally shoot and loosen the scope, move it 20 degrees and tighten. Adjust your POI to be dead on at 100yds. Then pick a target at say 800yds, click up to the proper elevation and see where your bullet impacts. That's all I'm saying. Even though Mr Tubbs' scope is canted I would bet it is parallel to the bore.
db