I had this issue so bad with my 338-416 Rigby Improved 45* with H50BMG, I had to change powder. As soon as the rounds came out of the press, they would start backing out while in the loading block!
My 300WM has this issue with 230gr Berger OTM's with just about every powder I put in there. I haven't lengthened the throat yet, and it is a SAAMI chamber, I will probably set back and run the A191 reamer in to fix it, but I just re-seat prior to shooting them.
I will also add that there is an important part of the loading procedure often overlooked. It is called the "Powder Packing Scheme". If you just dump powder into the case, especially powder that will be compressed, each dump of powder will be a jumbled random height in the case, the level of compression will also be different. This changes the burning of the powder between shots, which affects ES.
The best technique is to swirl the powder into the case with a powder funnel, no drop tube is required. This technique stacks the powder so uniformly that it is more consistent than a long drop tube. I did a test with clear 1/4" plastic pipe, as dumped loads varied in height quite a lot, the swirled charges practically stayed exactly the same height each time.
My ES dropped on untuned loads without even doing seating depth tests first using this method. Now this is only useful on loads that will be compressed, whether only slightly or heavily, although it works best on bulky powder loads like RETUMBO, RE33 & H50BMG or ANY compressed loads.
Cheers.