I do the "one shot zero", then refine if needed. There are reasons it isn't 100%; like the rifle doesn't group really well with that ammo, you may have "pulled" the shot a little, it was a clean/cold bore "flier" so to speak, etc. I know a couple guys that do this and only this that slaughter deer every year. For that matter I know a couple guys that are fine just having the local gun store mount their scope and boresight it with a collimator, they kill deer every year. The difference is they don't shoot ANY distance, mostly probably less than 100 yards. Now do I recommend their approach? Absolutely not! Where's the fun in shooting a rifle once (if at all) and calling it good?!
These are the same guys that cannot see how I can burn a barrel out or hit anything passed 300 yards.
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I bought a life long buddy (47 years together...outlasted 3 wives) and myself new 6.5 creeds in March...his was a lifetime achievement award for putting up with my B.S. and he's on a tight retirement budget. It didn't get warm enough here in Alberta, Canada until mid May to shoot them. We used up 8.5 lbs of powder until today. "WHAT'S BURNING OUT A BARREL"?