Are you wanting to keep the hides ? or does it matter if theirs a big hole in it? Our coyotes down here look raggedy all year their coats are never worth doing anything with so it doesen't matter if we blow holes in them.
The 6-284 with say a 55gr or 75gr bullet would be a lazer to 500yds and might not exit but if it does its gonna be messy
I know a couple guys that shoot 243 with the 55gr Ballistic tips at like 4200fps and the carnage is awsome , the 6mm 55gr Ballistic tip has a higher BC than the 55gr 22 cal ballistic tip and at that speed its kinda like a 220Swift on steroids