I loaded for 2 300 WSMs for several years. I had very good results from RL17, H4350 , and IMR4451. The RL17 can be affected by temp but gives very good velocities. IMR4451 is very temp stable and does not allow copper to build up. Performance wise I found 4350 and 4451 very similar. I also found in the 2 rifles I loaded for, an A7 Sako and a Kimber Montana with a Douglas barrel, I got the best ES and SD results using standard large rifle primers. You didn't ask about bullets but I got good results from Nosler 180 Accubonds and the Barnes 180 TTSX. I used the Barnes in Africa and on Elk with very good results. But, the most crazy accurate bullet I every shot in both of them was the Berger 190 VLD Hunter. It was crazy accurate for a couple of light barrel hunting rifles.