What Mikecr is implying here is efficiency, which I agree with 100% within reason.
Certain small bore cartridges with large cases will actually perform much better with an even slower powder than what is generally recommended.
Example; 264WM has very little testing with new powders, the companies just don't see the need when they are promoting their new stuff…
So, when powders like Retumbo and N570 aren't filling the case above 85-90%, to get better fps per grain of powder, you need to look to powders like H50BMG, US869 and RE33.
When I switched to RE33 and US869, the cartridge really opened up the realm of high velocity and made the cartridge more efficient.
Disclaimer! This testing was done on a custom rifle, with a custom match grade minimum chamber, custom throat length at .220" long and different experimental leade angles in a 8" twist 29" barrel.
A standard throated rifle will most likely NOT get the velocities this rifle did with these powders as the expansion ratio is too small.
The most efficient powder is the one that gains the highest velocities at or just under max pressure without causing an overbore situation. Which is to say that a lot of powder is being burned outside of the barrel.
The top 3 powders listed across several manuals for whichever bullet weight are generally the most efficient.
Their fps per grain of powder is highest in most applications, Nosler had a good write up on this subject in one of their manuals, just can't remember which one.
Cheers.