Yes the 300,400,500 marks will be more like 245,325,410 or something like that with super sonic ammo but still useable with a drop chart or some practice. I only shoot the subsonic which is extremely different in trajectory and would be more like 120,140,160.
Go to nikon sport optics, select riflescopes "spot on" program. Then select the 223 scope and enter the 300 whisper bullet and velocity etc. to see how your 300 trajectory stacks up on your reticle. You can use that same info to manipulate your dials effectively. Once you figure this out you could go to custom turret systems and spend $25 bucks to get a pack of labels to relabel your turret at those distances or kenton custom turrets $109 for a hole new turret marked to mach your trajectory.