My experience with the .338-.300 RUM or the "Edge" is that the comfortable accuracy load with the 300 SMK is around 2800 fps. You can run them faster, but the ES goes up and the brass takes a beating.
My .338-.408 shoots the 300 SMK at 3200 fps, and with a custom 27 moa base I can just touch 2000 yards with the 8x32 NXS.